Search results for "régulation transcriptionnelle"
showing 3 items of 3 documents
Etude de la régulation transcriptionnelle des lymphocytes T CD4 dans un contexte de cancer : application en immunothérapie anticancéreuse
2015
Immune surveillance of tumors is based on the ability of effector cells of the immune system to detect and eliminate the cancer cells. Notwithstanding, the complete and spontaneous regression of established cancers was observed only in very few cases. The failure of cancer resolution by the immune system could result from the combination of several factors: i) inadequate immune response related to a low tumor immunogenicity, ii) incompetent immune system consecutively to induced or acquired immunodeficiencies and iii) the selection of resistant tumor variants able to thwart immune surveillance or subverting immune responses. Developing novel cancer immunotherapy strategies leading to potent…
Persistance and adaptation of Listeria monocytogenes in the soil : role of the communication system Agr
2014
Listeria monocytogenes is a ubiquitous bacterium responsible for listeriosis, a food-borne disease. This pathogen has been isolated from various environments of which the telluric environment. The presence of L. monocytogenes in soil can increase health hazards due to the risk of transfer to vegetables, animals and animal products and water. Considering the role of soil in the circulation of pathogens from farm environment to plant and animal products and eventually to foodstuff, it is critical to identify intrinsic and extrinsic factors that drive the fate of L. monocytogenes in soil. Genome-wide and transcriptomic analyses found that an important part of the genome of L. monocytogenes (7.…
Persistance et adaptation de Listeria monocytogenes dans le sol : rôle du système de communication Agr
2014
Listeria monocytogenes is a ubiquitous bacterium responsible for listeriosis, a food-borne disease. This pathog•en has been isolated from varions environments of which the telluric environment. The presence of L. monocytogenes in soi! can increase health hazards due to the risk of transfer to vegetables, animais and animal products and water. Considering the role of soil in the circulation of pathogens from fann environment to plant and animal products and eventually to foodstuff, it is critical to identify intrinsic and extrinsic factors that drive the fate of L. monocytogenes in soi!. Genome-wide and transcriptomic analyses found that an important part of the genome of L. monocytogenes (7…